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Lettuce Regina dei Ghiacci means Ice Queen Lettuce. You can pick them before they head up or after; same great taste and texture. Usually, work well during the summer heat. Either start inside 6 weeks before setting out, 2-3 seeds/cell, thin to one. Set out six-week transplants from 3-4 weeks before the last frost date until pretty much the middle of September. Space plants 12". If direct seeding, one seed every 2", initially thin to one every six inches. Pick the middle one at the baby size and let the other grow to a full-size head.